Orodispersible tablets also known as fast dissolving tablets disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate orodispersible tablets of Granisetron HCl by using Indion 234s disintegrant as it is efficient disintegrant in low concentration which is equally efficiently with hydrophilic and hydrophobic formulations, especially with the latter where the conventional disintegrants are ineffective. Orodispersible tablets were formulated by using conventional disintegrants and Indion 234s. Indion 234s was characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, and loss on drying. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in-vitro and in-vivo disintegration time, in-vitro dissolution and stability studies. From the results, it could be concluded that Indion 234s could be used as disintegrant in the formulation of orodispersible tablets.
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